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Enzyme involved in DNA replication that joins individual nucleotides to produce a DNA molecule DNA ligase A linking enzyme essential for DNA replication; catalyzes the covalent bonding of the 3' end of one DNA fragment (such as an Okazaki fragment) to the 5' end of another DNA fragment (such as a growing DNA … –µâ– P Ñ theme/theme/theme1.xmlPK- ! The okay book, fiction, history, novel, Animated overview of DNA replication.Friday, 10 December 2010. 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