doi: 10.1136/bmj.n48. However, the practical application of this ethical concept has proven far from straightforward. Tingley K, Coyle D, Graham ID, Chakraborty P, Wilson K, Potter BK; Canadian Inherited Metabolic Diseases Research Network. 2020 Dec;5(12):e003456. trials in contexts of high‐mortality diseases are morally suspect because equipoise does not exist between a standard of care that offers little prospect of clinical benefit and a UMI that might offer some clinical advantage. But randomization severs the link between what a participant receives and the recommendation of a treating clinician with an ethical duty to provide the best possible care for the individual person. Two features of medical research pose special challenges for the goal of ensuring respect and concern for the rights and interests of participants. Buy euipoise in Canada from Alpha North Labs. USA.gov. London AJ(1). Guarda le traduzioni di ‘equipoise’ in italiano. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. For example, randomization and blinding are commonly used to reduce selection bias and treatment bias.4 Controlling how interventions are allocated and what researchers and participants know about who is receiving which interventions helps to more clearly distinguish the effects of the intervention from confounding effects. doi: 10.1590/1678-4685-GMB-2020-0273. Finfer S, Chittock DR, Su SY, et al. Destabilizing the 'equipoise' framework in clinical trials: prioritizing non-exploitation as an ethical framework in clinical research. Comment on JAMA. From Wikipedia, The Free Encyclopedia. But requiring uncertainty of individual clinicians to conduct a clinical trial gives too much ethical weight to personal judgment, hindering valuable research without providing benefit to patients. Freedman's 'clinical equipoise' and sliding-scale all-dimensions-considered equipoise'. Alpha North Labs Equipoise is a derivative of testosterone, which exhibits strong anabolic and moderately androgenic properties. The article is here. Guarda gli esempi di traduzione di equipoise nelle frasi, ascolta la pronuncia e impara la grammatica. | HOW DOES EQUIPOISE INFLUENCE THE INTERPRETATION OF THE STUDY. Science based public policies: Lessons from Covid19 on the use of randomized trials. The principle of equipoise reconciles 2 potentially conflicting ethical imperatives: to ensure that research involving human participants generates scientifically sound and clinically relevant information while demonstrating proper respect and concern for the rights and interests of study participants. 2010 Oct;11(4):271-9. doi: 10.1111/j.1466-769X.2010.00455.x. Traduzioni in contesto per "equipoise" in inglese-italiano da Reverso Context: We have reached a kind of equipoise. The concept of equi … A seminal paper by Miller and Brody [ 1] clearly laid the general framework on why we should abandon the term "clinical equipoise" in research. 2021 Jan 5;21(1):3. doi: 10.1186/s12874-020-01191-9. 1999 Jul;13(3-4):314-26. One of them, advanced by Paul Meier, was to stipulate that participation in clinical trials is commensurate with the everyday risks of not always getting one’s best choices in life. Equipoise, knowledge and ethics in clinical research and practice. The term was first used by Benjamin Freedman in 1987. Crossref Medline Google Scholar; 4. Am J Bioeth. Nurs Philos. doi: 10.1080/03605310701255750. BMJ. equipoise definition: 1. a situation in which things are perfectly balanced: 2. a situation in which things are…. [1] 1. Clinical equipoise was first proposed as a solution to the problem of randomisation 30 years ago. Ashcroft R. It is widely maintained that a clinical trial is ethical only if some form of equipoise between the treatments being compared obtains. COVID-19 is an emerging, rapidly evolving situation. Otherwise it is hidden from view. “In public health research, the justification for randomly assigning participants is based on clinical equipoise.This means that clinical trials are implemented only when, the researchers have substantial uncertainty (doubt) about the expected impact (efficacy) of the intervention (drug).The researchers may arrive at this conclusion after having reviewed the available research in the field. equipoise. This site needs JavaScript to work properly. Freedman B. Equipoise and the ethics of clinical research. • Accessibility. Orphanet J Rare Dis. Should the investigator discover that one treatment is of superior therapeutic merit, he or she is ethically obliged to offer that treatment. N Engl J Med. Behavioral equipoise: a way to resolve ethical stalemates in clinical research. In the final sections of the article, we elaborate on the non-exploitation framework for the ethics clinical research and indicate issues that warrant further inquiry. HHS Introduced as a term by Freedman in 1987, equipoise is “a state of genuine uncertainty on the part of the clinical investigator regarding the comparative therapeutic merits of each arm in a trial.” 2021 Jan 20;44(1 Suppl 1):e20200273. Equipoise was around even before Dianabol, Anadrol and many other steroids. Equipoise definition, an equal distribution of weight; even balance; equilibrium. No solid data exist on the infectivity of those who have been vaccinated, on how long the vaccine protects against COVID-19, on how that protection might differ across populations, or on the long-term safety profile of the vaccine. Intensive versus conventional glucose control in critically ill … Da Dicios.com, il miglior dizionario online inglese → italiano gratuito. Falsified research is perhaps so profoundly corrosive because it strikes at a fundamental tenet of ethical research—equipoise. • Notice J Med Philos. NIH "She laughed." Contextual equipoise: a novel concept to inform ethical implications for implementation research in low-income and middle-income countries. Genet Mol Biol. Equipoise (Boldenone Undecylenate) 10ml – 250mg/ml. It was mainly used as veterinary medicine. Virtual controls as an alternative to randomized controlled trials for assessing efficacy of interventions. The ethics of clinical research requires equipoise--a state of genuine uncertainty on the part of the clinical investigator regarding the comparative therapeutic merits of each arm in a trial. Copyright © American Medical Association. The ethics of clinical research requires equipoise--a state of genuine uncertainty on the part of the clinical investigator regarding the comparative therapeutic merits of each arm in a trial. Other proposals have been suggested. Verweij published Equipoise in public health research | Find, read and cite all the research you need on ResearchGate The principle of equipoise states that, when there is uncertainty or conflicting expert opinion about the relative merits of diagnostic, prevention, or treatment options, allocating interventions to individuals in a manner that allows the generation of new knowledge (eg, randomization) is ethically permissible. Meaning of Clinical equipoise. 2000 Aug;25(4):399-426. doi: 10.1076/0360-5310(200008)25:4;1-A;FT399. equipoise - definizione, significato, pronuncia audio, sinonimi e più ancora. eCollection 2021. Eds. Equipoise no longer exists with regard to preventing COVID-19 symptoms in the short term. 2007; 32:151–165. Clinical equipoise and the incoherence of research ethics. Please enable it to take advantage of the complete set of features! According to this concept of "clinical equipoise," the requirement is satisfied if there is genuine uncertainty within the expert medical community--not necessarily on the part of the individual investigator--about the preferred treatment. The degree of uncertainty necessary for ethical conduct of a clinical trial is the subject of ongoing debate. Equipoise in Research: Integrating Ethics and Science in Human Research. Contact your institution's library to ask if they subscribe to McGraw-Hill Medical Products. Stakeholder perspectives on clinical research related to therapies for rare diseases: therapeutic misconception and the value of research. Equipoise, a state of uncertainty about the relative merits of 2 or more treatments or therapeutic approaches, is fundamental to the ethical conduct of clinical research. ... Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial. Medical ethics A state of uncertainty regarding the pros or cons of either therapeutic arm in a clinical trial. This JAMA Guide to Statistics and Methods reviews the concept of equipoise, which allows for randomization of interventions while also respecting the rights of human subjects in clinical research. Fried asserted that there should be an “indifference requirement” when an … I suggest an alternative concept of equipoise, which would be based on present or imminent controversy in the clinical community over the preferred treatment. J Med Philos. This site uses cookies to provide, maintain and improve your experience. Equipoise is still considered a vital condition in the ethical approval of trials since it guarantees that no participant receives care known to be inferior to any available alternative. Equipoise is traditionally defined as a state of genuine uncertainty on the relative value of 2 approaches being compared in a trial. The term was first used by Benjamin Freedman in 1987. https://jamaevidence.mhmedical.com/content.aspx?bookid=2742§ionid=233567451. 2021 Feb 2;372:n48. Second, medical research involves exposing people to interventions whose risks and potential therapeutic, prophylactic, or diagnostic merits may be unknown, unclear, or the subject of disagreement within the medical community. Inflections of 'equipoise' (v): (⇒ conjugate) equipoises v 3rd person singular equipoising v pres p verb, present participle: -ing verb used descriptively or to form progressive verb--for example, "a singing bird," "It is singing." 1. a situation in which things are perfectly balanced: 2. a situation in which things are…: Vedi di più ancora nel dizionario Inglese - Cambridge Dictionary Their paper argued that the concept of … It was also used as a clinical medicine for humans but was quickly discontinued. Such practitioners may therefore regard it as unethical to randomize study participants to direct laryngoscopy because they consider it to be an inferior intervention. doi: 10.1136/bmjgh-2020-003456. Would you like email updates of new search results? A domestic steroid source. Fourteen years after Fried introduced the equipoise requirement, Freedman (1987: 142) argued that Fried’s equipoise requirement was far too stringent or too fragile and “poses a practical threat to clinical research” in that it rendered far too many RCTs unethical. Integrating Ethics and Science in Human Research. 1987 Jul 16;317(3):141–5. Epub 2011 Jul 11. This div only appears when the trigger link is hovered over. Seward N, Hanlon C, Murdoch J, Colbourn T, Prince MJ, Venkatapuram S, Sevdalis N. BMJ Glob Health. 2011 Aug;8(4):408-16. doi: 10.1177/1740774511409600. First, to generate reliable information, research often involves design features that alter the way participants are treated. Learn more. Equipoise should be amended, not abandoned. Effect of redundant clinical trials from mainland China evaluating statins in patients with coronary artery disease: cross sectional study. Should the investigator discover that one treatment is of superior therapeutic merit, he or she is ethically obliged to offer that treatment. 1,2 The principle of equipoise reconciles 2 potentially … Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. In the study by Lascarrou et al,3 patients were randomized to undergo intubation with the video laryngoscope or the direct laryngoscope, independent of the preference of the treating physician. 2011 Feb;11(2):1-8. doi: 10.1080/15265161.2010.540061. If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Terms of Use Philip S. Barie, ... Joseph J. Fins, in Surgical... Clinical Development: Ethics and Realities. “Theoretical” equipoise It turns out that the term equipoise (“equal weight”) was introduced into the domain of clinical research in 1974 by Charles Fried in a textbook on research ethics. Clinical Equipoise Research in the Intensive Care Unit: Ethical and Methodological Issues. 1 After its inception, equipoise became rapidly embraced as a necessary condition for randomization in clinical trials. With regard to other important outcomes, equipoise remains. Clipboard, Search History, and several other advanced features are temporarily unavailable. equipoised NLM Share this: Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) Click to share on LinkedIn (Opens in new window) Please consult the latest official manual style if you have any questions regarding the format accuracy. 2021 Jan 12;16(1):26. doi: 10.1186/s13023-020-01624-0. https://jamaevidence.mhmedical.com/content.aspx?bookid=2742§ionid=233567451. ; NICE-SUGAR Study Investigators. The principle of equipoise states that, when there is uncertainty or conflicting expert opinion about the relative merits of diagnostic, prevention, or treatment options, allocating interventions to individuals in a manner that allows the generation of new knowledge (eg, randomization) is ethically permissible. This compound was first released on the market back in the 1960s. Edward H. Livingston, and Roger J. Lewis. Prevention and treatment information (HHS). McGraw-Hill Concise Dictionary of Modern Medicine. Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial. How to use equipoise in a sentence. 2017 Feb 7;317(5):483-493. © … Jia Y, Wen J, Qureshi R, Ehrhardt S, Celentano DD, Wei X, Rosman L, Wen Y, Robinson KA. Clin Trials. BMC Med Res Methodol. | Che cosa è equipoise? | 1,2 The principle of equipoise reconciles 2 potentially conflicting ethical … All rights reserved. equipoised v past verb, past simple: Past tense--for example, "He saw the man." Bioethics. Author information: (1)Department of Philosophy, Carnegie Mellon University, Pittsburgh, Pennsylvania. Equipoise definition is - a state of equilibrium. Download Citation | On Jan 1, 2012, M.F. Clearly, equipoise highlights the tension between the therapeutic aims of medicine and the scientific aims of research. See more. Therefore, it is important to understand the role of conflicting expert medical judgment in establishing equipoise and how this principle applies to the trial conducted by Lascarrou et al.3. • Privacy Policy The current understanding of this requirement, which entails that the investigator have no "treatment preference" throughout the course of the trial, presents nearly insuperable obstacles to the ethical commencement or completion of a controlled trial and may also contribute to the termination of trials because of the failure to enroll enough patients. KEYWORDS CIOMS guidelines, Ebola, equipoise, public health emergencies, research ethics, right to try It is defined as a state of disagreement or uncertainty in the informed, expert medical community about the relative clinical merits of the intervention arms in a trial.1 This state of equipoise may mean that there is insufficient evidence to warrant a judgment that one intervention in … Finally, the difficulties with clinical equipoise cannot be resolved by viewing it as a presumptive principle subject to exceptions. The principle of equipoise states that, when there is uncertainty or conflicting expert opinion about the relative merits of diagnostic, prevention, or treatment options, allocating interventions to individuals in a manner that allows the generation of new knowledge (eg, randomization) is ethically permissible.1,2 The principle of equipoise reconciles 2 potentially conflicting ethical imperatives: to ensure that research involving human participants generates scientifically sound and clinically relevant information while demonstrating proper respect and concern for the rights and interests of study participants.1, Lascarrou et al3 reported the results of a randomized trial designed to investigate whether the “routine use of the video laryngoscope for orotracheal intubation of patients in the ICU increased the frequency of successful first-pass intubation compared with use of the Macintosh direct laryngoscope.” Intubation in the intensive care unit (ICU) is associated with the potential for serious adverse events, and video laryngoscopy in the ICU has gained support from some clinicians who believe it to be superior to direct laryngoscopy. EQUIPOISE: traduzioni in italiano, sinonimi, pronuncia e definizioni in inglese.
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